Like all retinoids, both adapalene (Differin) and tretinoin (Retin-A) bind to retinoic acid receptors (RARs) on keratinocyte cells in the skin. So does anyone have any experience with a second round of purging after changing retinoids? Finacea (azelaic acid 15% gel) works just as well as a topical retinoid (similar to Retin-A) called adapalene for women with adult acne. Bakuchiol does have some additional advantages compared to retinol. "Topical adapalene 0.1% gel was given to group A while topical tretinoin 0.025% gel was given to group B for once daily application. So you decided to try out a retinoid.Congratulations on trying what dermatologists universally agree to be “the most useful anti-aging ingredient around.” It also helps with acne, so good job on finding a beauty product with actual multi-uses!. Anti Aging Chinese Herb Pho Tee Anti Aging Doctors In Georgia Jennifer Lopez Anti Aging Affordable Is Differin Gel For Anti Aging. The two most popular being tretinoin, an anti-aging all star known widely by it’s brand name Retin-A, and Accutane (isotretinoin) — an oral prescription drug for severe cases of acne. Tret is already knocking them out. Derms tell you it isn’t for anti-aging. Adapalene is an analogue of tretinoin, which means it was designed to look and act just like it, but with a few extra advantages. He also claimed that retinoid purges don't exist.. which is sketchy. http://www.ncbi.nlm.nih.gov/pubmed/23725303 - Differin 0.3 is similar to tretinoin 0.05 in terms of efficacy. "The great thing is that now adapalene is over-the-counter, so patients can buy it without a prescription." Just switch over. It's been about 2 months on tret (I stopped the retinol). Retin-A (tretinoin) Cream and Gel and Differin (adapalene) are retinoids (a form of vitamin A) used for the topical treatment of acne vulgaris. http://www.ncbi.nlm.nih.gov/pubmed/23725303, http://www.ncbi.nlm.nih.gov/pubmed/11843231, http://www.ncbi.nlm.nih.gov/pubmed/9990420. (1) A retinoid is simply a derivative of vitamin A. La Roche-Posay's latest skin-care innovations include the launch of Effaclar Adapalene Gel 0.1% Acne Treatment, the newest over-the-counter adapalene … What do you mean by a weaker retinoid? Clear90 is a free app that helps you keep track of your progress with Differin–all the way to clear skin–in just 90 days. Retin-A is a brand name for the drug tretinoin. It has been more effective for me as well. I’m still in the purge phase so I’m waiting for the benefits to kick in. I used Adapalene 0.1% before moving to Tret. Differin Gel (adapalene 0.1%) is the first and only retinoid available OTC for the treatment of acne. I'm really intrigued by the studies you found about Diff 0.1 being similar in strength to 0.025 Tret - I've been looking for a comparison for a while now! When really, it's bringing the acne that was already there to a head (therefore making it look worse before it gets better). Adapalene Vs Tretinoin: Differin, Treclin Gel, and Other Topical Acne Treatments Compared. After a couple of visits, she wasn’t willing to switch me to tret so I ended up ordering from a pharmacy online without a prescription, which actually ended up being considerably cheaper than the cost of EpiDuo + paying for a doctor to completely ignore my wishes. http://www.ncbi.nlm.nih.gov/pubmed/11843231 - Differin 0.1 and Tretinoin 0.025 offer comparable efficacy, but Differin is less irritating, http://www.ncbi.nlm.nih.gov/pubmed/9990420 - only investigator-masked, reaches basically the same conclusion as the above study, but one line stood out to me - "When comparing patients who had 75% or greater improvement in open comedones, adapalene was shown to be significantly more effective than tretinoin", New comments cannot be posted and votes cannot be cast, More posts from the SkincareAddiction community, Press J to jump to the feed. Trifarotene is the newest retinoid on the block, expected to become available in the US by end of year. Finacea was tested for 9 months against the topical adapalene gel in a 2014 study.. Please contact the moderators of this subreddit if you have any questions or concerns. It likely could have similar benefits to Tret but it can’t be said for sure. Skin peeled and was more irritating. I was so excited to get this tret prescription! I know adapalene is gentler but adapalene 0.1 is equivalent to tretinoin 0.025 in terms of efficacy, according to the pubmed links I found (I'll find the articles when I'm free later today). Derm changed my script from tret to differin because of the irritation I was getting from tret + he said differin is more effective on CCs. There are tons of over-the-counter (OTC) acne treatment products out there. As a result, it is gentler than the other prescription retinoids. If the irritation gets bad then just drop back to every other night. The main difference is that adapalene is not as harsh on the skin as tretinoin, and apparently works with different receptors in the skin than tretinoin. Adapalene vs. Tretinoin: What do they do? Retin-A is a brand name; tretinoin is the name of the active ingredient. I live in Asia, so I was able to get friends who were travelling to neighbouring countries to buy tret for me over the counter. Tretinoin vs Adapalene. Retin-A vs. Tretinoin . Acne scars are disappearing (Differin didn’t do that) and some fine lines around my eyes are disappearing. I do feel like my skin is smoother and my PIH is fading albeit very slowly. Tret is also amazing for fading acne scars (PIE). Acne isn’t my main issue anymore and I just wanted to get rid of the scars (PIE mainly). You should not stop using adapalene if your acne seems worse at first, unless irritation or other symptoms become severe. It came in the form of blind pimples and I had small red itchy patches on mostly the left side of my face. First resolve your irritation issue by just using gentle products and no topicals for a few days and then when you think your skin can tolerate it, use the Differin every other day for a week or two. I have also started to notice my fine lines at the nasolabial folds are not as pronounced. Then you can move up to daily if your skin is responding okay. Press question mark to learn the rest of the keyboard shortcuts. Thank you for all of the information though! Instead, adapalene only binds to specific receptors RAR-β and RAR-γ. 025% gel, both topical treatments for acne, in a once‐daily dosage regimen for 12 weeks. I see. Simple said they all are just Vitamin A! From acne-fighting to anti-aging, there aren’t many topical skin care ingredients that can compete with the benefits of retinoids. I noticed alot of peeling on the corners of my mouth and I had some kind of a purge. I was wrong. I had a really similar experience! Differin is available over-the-counter (OTC). Hi everyone, I would like to share a research paper I found.